Browns vs. Panthers: Game picks, best bets for Week 1 NFL season

The Cleveland Browns and Carolina Panthers will face off Week 1 to kickoff the 2022 NFL season. Kickoff is set for 1:00 p.m. ET from Bank of America Stadium in Charlotte, NC, while the game will be broadcast on CBS.

Here, we’ll take a look at our picks for best bets for Browns vs. Panthers in Week 1 of the NFL season.

All odds come courtesy of DraftKings Sportsbook.

Browns vs. Panthers odds

Spread: Panthers -1.5 (-110)
Point total: O 42 (-110), U 42 (-110)
Moneyline: Panthers (-125), Browns (+105)

Our picks, best bets

Pick against the spread: Panthers -1.5

This is a revenge game for Baker Mayfield and I think he’s going to have a big game. With Jacoby Brissett at quarterback, the Browns will have a hard time scoring. Brissett was 2-3 as a starter last season. The Panthers offense has a number of playmakers and a healthy Christian McCaffrey which will be the difference maker.

Over/under: U 42 (-110)

I think this score will be somewhere around 14-10 with the Panthers winning. Both teams like to run the ball which will keep the clock ticking. 58.8% of Browns games went under last season. Their defense should be good and their offense will struggle. This game has the perfect makings for the under.

Player prop: Christian McCaffrey over 46.5 receiving yards (-115)

In Week 1 last season, McCaffrey had 89 receiving yards. With Matt Rhule at head coach, the Panthers have shown they will throw the ball to McCaffrey a bunch to give him a chance to make plays with space in front of him. To build Mayfield’s confidence, look for Carolina to throw some underneath passes and screens and McCaffrey to be involved in a majority of those.

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