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2022 NFL TNF Week 1 DraftKings Showdown Strategy, Picks for Bills at Rams

Pat Mayo gives NFL DraftKings strategy and makes his 2022 TNF Week 1 DraftKings Showdown picks for Bills at Rams.

Pat Mayo and Justin Freeman discuss the strategy behind creating winning lineups in Single-Game DraftKings Showdown contests against large- and small-field GPP tournaments and how to use the proper tools to your advantage before making 2022 TNF Week 1 DraftKings Showdown Picks for the NFL season opening game: Buffalo Bills at Los Angeles Rams.

Get the Link to the RAKE FREE PME Week 1 DraftKings Contest Here

Week 1BUF/LAR DK Showdown | W1 DraftKings | Projections

NFL WIN TOTALSAFC: East/North | West/South NFC: East/South | West/North

Rankings Lists — 9/2 Final Update | Breakdown | Top 150 | RB | WR | TE | QB

NFL PICKSAwards Picks | Best Bets | How to Bet NFL

DraftKings Lineup Tools — Optimizer | Game Sims | Player vs Player Compare

Podcasts — YouTube | Apple | Spotify | Insta | Google | Twitter | E-Mail

How To Bet on NFL Guide + Strategy | Podcast | For Beginners | Gambling Myths

TNF Week 1 DraftKings Showdown Picks: Show Index

WATCH/LISTEN: BUF at LAR DraftKings Showdown Picks & Strategy

  • 3:08 2022 DraftKings Showdown Strategy
  • 7:15 Rules/Positions Captain’s Spot
  • 19:39 Have to play 150 Lineups
  • 22:27 Contest Selection
  • 23:44 BUF at LAR
  • 37:22 TNF W1 DK Picks

TNF Week 1 DraftKings Showdown Captain & Flex Distribution

After simulating the game 10,000 times, this is the distribution for the top three players in the Week 1 TNF for DraftKings Showdown.

TOOLS: Custom Simulations, Projection Builder & Optimizer

Top Captian & Flex Distribution BUF/LAR
Run The Sims

TNF Week 1 DraftKings Showdown Projections

After simulating the game 10,000 times, these are the median projections for the top five DraftKings scorers in the Week 1 TNF game.

TOOLS: Custom Simulations, Projection Builder & Optomizer

Week 1 TNF BUF/LAR Projections
Run the Sims

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Pat Mayo is an award-winning video host and producer of long and short-form content, and the host of The Pat Mayo Experience daily talk show. (Subscribe for video or audio). Mayo (@ThePME) won the 2020 Fantasy Sports Writing Association Daily Fantasy Writer of the Year and Golf Writer of the Year awards, along with the Fantasy Sports Trade Association Best Sports Betting Analyst award, and is a finalist for three FSWA Awards in 2022 (Best Podcast, Daily Fantasy Writer of the Year, Golf Writer of the Year). His 24 FSWA nominations lead all writers this decade and are second-most all-time.

Mayo has been recognized across multiple sports (Football, Baseball & Golf), mediums (Video, Writing & Podcasting), genre (Humor), and game formats (Daily Fantasy and Traditions Season Long). Beyond sports, Mayo covers everything from entertainment to pop culture to politics. If you have a fantasy question, general inquiry or snarky comment, ship it to Mayo at and the best will be addressed on the show.

I am a promoter at DraftKings and am also an avid fan and user (my username is ThePME) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skill and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.

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