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Illinois vs. Indiana picks and best bets for Week 1 Big Ten matchup

The Fighting Illini and Hoosiers meet on Friday in Bloomington. Here’s everything you need to know and a pick for the game.

Grant Gremel #16 and Donaven McCulley #0 of the Indiana Hoosiers celebrate a touchdown during the first quarter in the game against the Purdue Boilermakers at Ross-Ade Stadium on November 27, 2021 in West Lafayette, Indiana. Photo by Justin Casterline/Getty Images

The Illinois Fighting Illini will play the Indiana Hoosiers in Bloomington on Friday, September 2 at 8:00 p.m. ET. This Big Ten crossover matchup should be a spot where both teams think they can get a conference win to get closer to a bowl game,

Here’s all the data you’ll want, and a pick for the game!

SP+ Rankings

Illinois: No. 79 overall, No. 104 offense, No. 42 defense
Indiana: No. 86 overall, No. 98 offense, No. 67 defense

Injury update


RB Josh McCray - Questionable (knee)
QB Donovan Leary - Out indefinitely (undisclosed)


WR DJ Matthews, Jr. - Questionable (knee)


Against The Spread

Illinois: 0-0 ATS
Indiana: 0-0 ATS


Illinois: Over 0-0
Indiana: Over 0-0

Returning/Overall Talent from 247Sports

Illinois: No. 64 overall, No. 67 offense, No. 56 defense
Indiana: No. 30 overall, No. 28 offense, No. 37 defense

Current lines at DraftKings Sportsbook

Spread: Indiana -3
Total: 45
Moneyline: Indiana -150, Illinois +130

Opening line: Indiana -3
Opening total: 48.5


87 degrees, 6 MPH wind, 0% chance of rain

The Pick

Illinois +130

I’m going with Illinois for the upset here. The Illini have already played a Week 0 game and beat Wyoming 38-6, so they’ve clearly found a way to generate offensive production — something Indiana has not exactly been strong in the past few seasons. Sure, the Big Ten isn’t Wyoming, but Indiana isn’t Ohio State, either.

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