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Deebo Samuel injury: What status means for Week 12 fantasy football

Deebo Samuel is dealing with a hamstring injury ahead of Week 12. We break down what it means for fantasy football roster decisions.

Deebo Samuel #19 of the San Francisco 49ers runs after making a catch during the game against the Arizona Cardinals at Estadio Azteca on November 21, 2022 in Mexico City, Mexico. Photo by Michael Zagaris/San Francisco 49ers/Getty Images

Game status: Deebo Samuel is ACTIVE for Week 12.

Game day Update: Samuel is expected to play on Sunday, assuming he doesn’t aggravate the injury during pre-game warmups. The hamstring injury was a concern because Samuel has such a dominating presence on the ground. If he is active, you have to assume the team isn’t worried about any limitations regarding his game and how he is used.


Deebo Samuel’s status for Sunday currently sits in a gray area. The San Francisco 49ers wide receiver is officially listed as questionable with a hamstring injury, but he was able to get in some work as a limited participant in all three practices this week.

You may recall that Samuel missed a game with a hamstring injury earlier in the season. Head coach Kyle Shanahan sounded optimistic this week that Samuel’s hamstring issue this time around was “different,” but we might have to wait until Sunday to know more about his availability.

The Niners host the New Orleans Saints at 4:25 p.m. ET on Sunday.

Fantasy football implications

Samuel missed Week 8 with a hamstring injury. After the team’s bye, he returned in Week 10. Last week, he caught seven passes for 57 yards and ran the ball three times for 37 yards and a touchdown.

If he can’t play, expect even more work for Christian McCaffrey and George Kittle. Fellow wideout Brandon Aiyuk could also see more targets.