The Big 12 is as wide open as a Power 5 conference can get, and both of these programs figure to be in contention for the title game in the end. Baylor opened up conference play with a 31-24 road win over the Iowa State Cyclones last weekend as Blake Shapen threw three touchdowns.
Oklahoma State has the advantage of entering its Big 12 schedule coming off a bye week after beating all three non-conference opponents by at least 14 points. The Cowboys crushed Arkansas-Pine Bluff 63-7 in their last game on September 17.
Baylor is a 2.5-point favorite on DraftKings Sportsbook with -135 moneyline odds, making Oklahoma State a +115 underdog. The over/under is set at 55.5.