clock menu more-arrow no yes mobile

Filed under:

NFL picks, Week 6: Predicting every game against the spread

The NFL is back for Week 6, which means it’s time for a pick of every game against the spread!

Justin Herbert #10 of the Los Angeles Chargers runs with the ball during a 47-42 win over the Cleveland Browns at SoFi Stadium on October 10, 2021 in Inglewood, California. Photo by Harry How/Getty Images

Week 6 got underway on Thursday with the Bucs holding off a game Eagles squad on Thursday Night Football. The Bucs looked like they might blow the game open, but Jalen Hurts and company made it interesting in the fourth quarter. Now, we’re about ready to get going with some early Sunday football in London followed by the normal 1 p.m., 4 p.m., and SNF slate.

We’re back with more picks against the spread. I went 7-9 overall last week, but did manage to go 5-0 with my best bets. That moves me to 14-11 on best bets and 36-44 overall. If I’m going to get anything right, it might as well be the best bets!

All odds below come courtesy of DraftKings Sportsbook. Each week, I’ll also pull out my five best bets. These are based on Sunday morning lines, so they’re not necessarily best bets I grabbed earlier in the week before some of the current line movement.

Chargers (+2.5) over Ravens
Panthers (+2.5) over Vikings
Texans (+10) over Colts
Chiefs (-6.5) over Washington
Cowboys (-3.5) over Patriots

Here are all my picks for Week 6.

Bucs vs. Eagles (+6.5): Eagles — WIN
Dolphins vs. Jaguars (+3): Dolphins Jaguars (8:25 a.m. — with all the injuries, we’re pivoting to Jacksonville on this pick)
Chargers vs. Ravens (-2.5): Chargers
Vikings vs. Panthers (+2.5): Panthers
Packers vs. Bears (+5.5): Bears
Bengals vs. Lions (+3.5): Lions
Texans vs. Colts (-10): Texans
Rams vs. Giants (+9): Rams
Chiefs vs. Washington (+6.5): Chiefs
Cardinals vs. Browns (-3.5): Cardinals
Raiders vs. Broncos (-4): Broncos
Cowboys vs. Patriots (+3.5): Cowboys
Seahawks vs. Steelers (-5): Steelers
Bills vs. Titans (+5.5): Titans

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO/NH), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ) or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ NH/WY). AZ/CO/IL/IN/IA/MI/NH/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. See for full terms and conditions.