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How the public is betting 49ers vs. Cardinals on Saturday in Week 16

The Cardinals host the 49ers on Saturday of Week 16. We discuss how the public is picking this one.

Head coach Kliff Kingsbury of the Arizona Cardinals and head coach Kyle Shanahan of the San Francisco 49ers shake hands after the game at Levi’s Stadium on November 17, 2019 in Santa Clara, California. Photo by Thearon W. Henderson/Getty Images

The NFL is broadcasting a Saturday tripleheader, and the middle game features the Arizona Cardinals hosting the San Francisco 49ers. The game kicks off at 4:30 p.m. ET, and the NFL is doing something unique with the broadcast. It will be available on TV in the two local markets, but otherwise will only be available via streaming on Amazon Prime and Twitch.

The Cardinals enter the game with an 8-6 record and can clinch a playoff berth with a win and a Bears loss. The Cardinals have a host of players listed as questionable, but really are about as healthy as a team can expect in Week 16. Cornerback Dre Kirkpatrick and tight end Maxx Williams are the two most concerning having not practiced on Thursday.

The 49ers are 5-9 and playing out the string. They do get George Kittle back, but will be starting third string quarterback C.J. Beathard and be without wide receiver Deebo Samuel and running back Raheem Mostert on offense. The defense will be missing cornerback Richard Sherman and safety Jimmie Ward.

With all that being said, where are the bettors placing their money as we get closer to game time? Let’s check it out below! All the odds and info were provided by DraftKings Sportsbook.

Point Spread

The Cardinals opened as 3.5-point favorites and the line has climbed to 5.5 as of Saturday morning. The betting public is heavily backing the favorites, with 91 percent of handle and 84 percent of bets on Arizona.

Is the public right? Getting Kittle back is a boost to the 49ers offense, but there are just too many injuries here. Divisional games are often tight, but I think the 49ers quarterback position is a mess for now and the losses of Sherman and Ward cannot be underestimated.


The point total opened at 50 and has come down to 48.5. This comes in spite of the betting public backing the over with 54 percent of handle and 66 percent of bets.

Is the public right? I lean under, but the big concern is C.J. Beathard turnovers setting up the Cardinals with a host of short-field opportunities. That’s what would send this game over.


The Cardinals opened at -200, while the 49ers opened at +163. As of Saturday morning, the Cardinals are -240 while the 49ers are +205. The public likes Arizona to win this one, with 89 percent of the moneyline handle and 84 percent of bets on the favorites.

Is the public right? I don’t think an upset would be entirely shocking, but the Cardinals are the better team and should be able to handle their business.

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