The Cardinals lost a tough back-and-forth game against the Bucs in which both Kyler Murray and Christian Kirk had monster performances. Arizona has dramatically brought down their pace in recent weeks. They were fourth in plays per game during the first six weeks of the season. Since Week 7, they rank ahead of only the Redskins in that statistic. Why the slowdown? Arizona is looking to hide their defense, which ranks 28th in Football Outsiders DVOA. Offensively, the team has still been productive, ranking 15th in DVOA and 17th in yards per play.

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San Francisco just lost their first game of the season, but should be back for vengeance up against another division opponent in Arizona. They just beat the Cardinals two weeks ago on Thursday Night Football, and will now be playing at home. The Niners have been phenomenal, particularly on defense. They have the top pass defense by DVOA, and only the Patriots have allowed less adjusted net yards per pass attempt than San Francisco. The team is league-average on offense, ranking 16th in both rush and pass DVOA.

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Cardinals at 49ers

Betting Odds

Point Spread: Cardinals +11.5
Total Points: 46
Money Line: 49ers -560; Cardinals +425

Records

Overall 2019: Cardinals 3-6-1; 49ers 8-1
ATS 2019: Cardinals 7-3; 49ers 5-4
O/U 2019: Cardinals 6-4; 49ers 4-5

Injury Report

Cardinals: RB Chase Edmonds (hamstring) out, OL Justin Murray (knee) questionable, CB Tramaine Brock (hamstring) questionable
49ers: OL Joe Staley (finger) out, TE George Kittle (knee) doubtful, RB Matt Breida (ankle) doubtful, K Robbie Gould (quad) doubtful, WR Emmanuel Sanders (ribs) questionable

Notable Prop Bets

Cardinals Total Touchdowns - Over 1.5 -167, Under 1.5 +125
49ers Total Points - Over 28.5 -115; Under 28.5 -113
First to 25 Points - Cardinals +600, 49ers -180, Tie +200
First Team to Score - Cardinals +165, 49ers -235

Betting Trends

• The 49ers have won each of their last six Sunday games.
• The 49ers have failed to cover the spread in 17 of their last 20 games as favorites.
• Five of the 49ers’ last six games against NFC West opponents have gone OVER the total points line.

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Odds and lines subject to change. See website for details.