The undefeated San Francisco 49ers host the 7-2 Seattle Seahawks for a critical NFC West battle. San Francisco has dominated defensively for much of the season, while Russell Wilson often has willed wins into existence for his team.

Last week we saw 49ers quarterback Jimmy Garoppolo break out against the Cardinals on Thursday Night Football, as he completed four touchdowns and threw for over 300 yards. Wilson also had his best statistical game of the year in a win over the Buccaneers, as he tossed five touchdowns and threw for 378 yards.

The 49ers come into this game riding hot, of course, but do have a significant injury concern with George Kittle’s availability currently up in the air. Their No. 1 target is an integral part of their offense, and his loss would hurt.

Linebacker Kwon Alexander suffered a torn pectoral last Thursday and was placed on IR, which is a blow to their defense, especially in underneath coverage. Robbie Gould is also hurting with a quad injury and has a “chance” to play according to coach Kyle Shanahan. If he can’t, we will see Chase McLaughlin take his spot. There is also good news on the injury front for San Francisco. They will get left tackle Joe Staley back after six weeks out due to a fractured fibula, which is a massive boost to both their run and pass game.

Josh Gordon joins his new team and should be able to suit up. He does have an ankle injury that needs to be monitored. But for the most part, the Seahawks are healthy as they travel down the coast to face their toughest matchup yet.

Matchups are crucial for fantasy, but it helps to see what the analytics are saying about potential performances. Looking at ESPN fantasy projections, Wilson has the highest fantasy projection despite the tough matchup. His ability has popped his whole career, but so far this season, he’s leading the MVP race. Coming off his break out game, Garoppolo had the 16th quarterback in fantasy points at 15.9.

We also get to see if Emmanuel Sanders can follow up his strong game and beat his 12.8 point projection. And of course, Josh Gordon will have all eyes on him as he starts his new job. His projection is low at 6.9 points, as his usage is still a mystery.

Overall, this game should be entertaining, but the flawless 49ers are favored by -6.5 at home. With Wilson, Seattle has a cheat code, though, and they will likely press it all game long.

Seattle Seahawks

QB Russell Wilson: 18.7
RB Chris Carson 13.2
RB Rashaad Penny: 4
WR Tyler Lockett: 13.3
WR DK Metcalf: 9.6
WR Josh Gordon: 5.8
TE Jacob Hollister: 3
K Jason Myers: 6.6
Seahawks D/ST: 6

San Francisco 49ers

QB Jimmy Garoppolo: 16
RB Tevin Coleman: 15.8
RB Matt Breida: 10.2
WR Emmanuel Sanders: 10.5
WR Deebo Samuel: 7.1
WR Dante Pettis: 4.4
TE Ross Dwelley: 5.6
K Chase McLaughlin: 8.7
49ers D/ST: 7.2